Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

Abstract: Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class drug which effective against a wide variety neoplasms. However, doxorubicininduced cardiotoxicity limits clinical utility drug. One major myocardial oxidative stress. Adhatoda vasica have been shown possess strong anti-inflammatory during reperfusion injury induced by doxorubicin in zebrafish model. Materials Methods: Cardiac was Zebrafish using doxorubicin. further supplemented antioxidants enzymes were analysed. also infected with MRSA anti-microbial activity A. Results: Supplementation extract reduces stress through improvement catalase, superoxide dismutase GSH activities subsequently lipid peroxidation. mediated inflammatory response tissue neutralized supplementation plant improves architecture. inhibiting growth has cause serious complications surgery prosthetic implantation. dose-dependent suppression virulence gens such as spA mecA. Conclusion: Therefore, may be useful controlling microbial infections complications. In conclusion, present study indicates that can Keywords: Doxorubicin, ischemia, Antioxidant, MRSA, vasica.